Cereal dietary fibre has well-established health benefits in terms of reducing serum cholesterol and cardio vascular disease and reducing the incidence of colon cancer. The mechanisms of these effects are poorly understood but it is likely that pre-biotic fermentation in the colon is a contributory mechanism. Previous collaborative studies have shown that the major dietary fibre component in wheat grain, arabinoxylan, has pre-biotic activity which is related to mass. This studentship will explore these... more
Turnover of regulatory proteins is a hugely important control mechanism in signalling and development in plants. Recently, we discovered that a specialised pathway of targeted protein degradation- the N-end rule pathway- regulates ABA signalling and seed oil mobilisation (Holman et al., 2009 PNAS USA) and acts as a sensor for hypoxia and nitric oxide (Gibbs et al., 2011 Nature; 2014, Mol. Cell). Others have shown important roles in leaf development and senescence (Graciet et al., 2011 TIPS). Thus this... more
The primary purpose of this project is to test the efficacy of the only EPA+DHA containing CsGM oil that is available globally as a potential replacement for FO in the human diet. In addition, the proposed experiments will increase understanding of the effect of the structure and composition of dietary oils on the metabolism of EPA and DHA in blood and on immune function. We will use immune cell function as the primary means of functional assessment as there is good evidence that EPA+DHA modulate... more
Fish-farming (aquaculture) plays a key role in producing animal protein is produced for human consumption. Aquaculture plays a vital role in feeding the world, and as the number of mouths to feed increases, its role in providing nutritious food continues to grow. Fish farming is more efficient than any terrestrial animal production system, but the Achilles heel of aquaculture is the requirement for omega-3 fish oils in the feeds of marine and salmonid species - this is because fish lack the capacity to... more
A fundamental challenge in modern crop science is the exploitation of big genomic data by linking variation in genotype to phenotype. Flowering time pathways are now recognised as master regulators of plant development, and as signal-processing machineries allowing plants to adapt to their environment. These genes affect all major reproductive processes from the timing of flowering, through inflorescence architecture, flower, fruit and seed development and finally seed vigour. The goal of the sLoLa BRAVO... more
The relationship between the type of wheat (modern bread wheats, emmer and spelt), the processing system and impacts on human physiological responses will be determined using dietary interventions.