Frederic Beaudoin

+44 (0) 1582 763 133 ext: +44 1582 938129
Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ
Past Projects
Project Leader
  • IDG/Manipulating epicuticular wax structure and composition to improve photosynthesis and increase the yield of Brassica oilseed crops
  • Rational metabolic engineering of oilseed fatty acid composition
  • Establishing a transatlantic platform for plant lipidomics
  • Genetic Improvement of Algae for Value Added Products (GIAVAP)
  • Designing oilseeds for nutrition and health

Capuano F, Bond Nicholas J, Gatto L,  Beaudoin, F , Napier JA,  Benvenuto E,  Lilley, KS and Baschieri, S  (2011) LC-MS/MS Methods for Absolute Quantification and Identification of Proteins Associated with Chimeric Plant Oil Bodies  ANALYTICAL CHEMISTRY  Vol 83  24:9267-9272


Konarev AV, Beaudoin F; Marsh J, Vilkova, NA , Nefedova LI , Sivri D ; Koksel H ; Shewry PR and Lovegrove A.Characterization of a Glutenin-Specific Serine Proteinase of Sunn Bug Eurygaster integricepts Put. (2011) J  AGRI. AND FOOD CHEM. Vol 59 6:2462-2470


Smooker AM, Wells R, Morgan C, Beaudoin F, Cho K, Fraser F, Bancroft I. (2011) The identification and mapping of candidate genes and QTL involved in the fatty acid desaturation pathway in Brassica napus. Theor Appl Genet. 122:1075-90


Venegas-caleron M; Beaudoin F; Garces R, Napier JA and Martinez-Force E (2010) The sunflower plastidial w3-fatty acid desaturase (HaFAD7) contains the signalling determinants required for targeting to, and retention in, the endoplasmic reticulum membrane in yeast but requires co-expressed ferredoxin for activity Phytochemistry 71(10):1050-1058


Roudier F; Gissot L ; Beaudoin F; Haslam R; Michaelson L; Marion J; Molino D; Lima A; Bach L; Morin H; Tellier F; Palauqui JC; Bellec Y; Renne C; Miquel M; DaCosta M; Vignard J; Rochat C; Markham JE; Moreau P; Napier J and Faure JD (2010) Very-Long-Chain Fatty Acids Are Involved in Polar Auxin Transport and Developmental Patterning in Arabidopsis. Plant Cell 22(2):364-375


Beaudoin F, Wu X, Li F, Haslam R, Markham JE, Zheng H, Napier JA and Kunst L (2009) Functional Characterization of the Arabidopsis thaliana β-Ketoacyl-CoA Reductase Candidates of the Fatty Acid Elongase. Plant Physiology 150(3): 1174-1191


Bach L; Michaelson LV.; Haslam R; Bellec Y; Gissot L; Marion J; Da Costa M; Boutin J; Miquel M; Tellier F; Domergue F; Markham JE.; Beaudoin F; Napier JA.; Faure JD (2008) The plant Very Long Chain Fatty Acid elongation dehydratase PASTICCINO2 is essential and limiting for plant development. Proc. Natl. Acad. Sci. USA 105 (38): 14727-14731


Venegas-Calerón M, Beaudoin F, Sayanova O, Napier JA. (2007) Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. J Biol Chem. Feb 282(5):2996-3003


Capuano F, Beaudoin F, Napier JA, Shewry PR. (2006) Properties and exploitation of oleosins. Biotechnol Adv. 2007 Mar-Apr;25(2):203-6.


Paul S, Gable K, Beaudoin F, Cahoon E, Jaworski J, Napier JA and Dunn TM (2006). Members of the Arabidopsis FAE1-like 3-ketoacyl-Coa synthase gene family substitute for the elop proteins of Saccharomyces cerevisiae. J. Biol. Chem. 281 (14): 9018-9029


Napier JA, Haslam R, Caleron MV, Michaelson LV, Beaudoin F and Sayanova O (2006) Progress towards the production of very long-chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age Physiologia Plantarum 126 (3): 398-406


Shewry PR.; Jenkins J.; Beaudoin F., Mills ENC (2006) Plant protein families as a basis for predicting the allergenicity of food proteins.. Allergy matters: new approaches to allergy prevention and management: 41-46 (Eds Glissen, LJ et al.) Publisher: Springer SBM; Dordrecht; Netherlands


Adams MJ, Antoniw JF and Beaudoin F (2005) Overview and analysis of the polyprotein cleavage sites in the family Potyviridae Molecular Plant Pathology 6 (4): 471-487


Napier JA, Beaudoin F and Sayanova O (2005) Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants European Journal of Lipid Science and Technology 107 (4): 249-255


Forsyth JL, Beaudoin F, Halford NG, Sessions RB, Clarke AR, Shewry PR (2005) Design, expression and characterisation of lysine-rich forms of the barley seed protein CI-2 Bioch et Biophys. Acta-Proteins and Proteomics 1747 (2): 221-227


Paul S, Gable K, Beaudoin F, Napier JA, Dunn TM (2004) Plant FAE1-like condensing enzymes substitute for the Elop proteins in Saccharomyces cerevisiae Mol. Biol. of the Cell 15: 1033 Suppl.


Shewry, P.R., Jenkins, J., Beaudoin, F. and Mills, E.N.C. (2004) The classification, functions and evolutionary relationships of plant proteins in relation to food allergens.  In:  Plant Food Protein Allergens (eds. E.N.C. Mills and P.R. Shewry)  Blackwell Science Ltd.


Napier JA, Beaudoin F, Michaelson LV, Sayanova O (2004) The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering Biochimie 86 (11): 785-792


Beaudoin, F. and Napier J.A. (2004) Biosynthesis and compartmentation of triacylglycerol in higher plants. G. Daum (Ed.) Lipid Metabolism and membrane Biogenesis Topics in Current Genetics (6), 267-287.


Slocombe S.P., Beaudoin F., Donaghy P.G., Hardie D.G., Dickinson J.R. and Halford N.G. (2004) SNF1-related protein kinase (SnRK1) phosphorylates class I heat shock protein Plant Physiol Bioch 42 (2), 111-116.


Sayanova, O.V., Beaudoin, F., Michaelson, L.V., Shewry, P.R., and Napier, J.A. (2003) Identification of Primula fatty acid D6-desaturases with n-3 substrate preferences FEBS 542, 100-104.


Garton, S., Michaelson, L.V., Beaudoin, F., Beale M.H., and Napier J.A. (2003) The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe, FEBS 538, 192-196.


Han, G., Gable, K., Kohlwein, S.D., Beaudoin, F., Napier, J.A. and Dunn, T.M. (2002) The Saccharomyces cerevisiae YBR159 Gene Encodes a Microsomal 3-Ketoreductase Required for Fatty Acid Elongation. J. Biol. Chem. 277, 35440-35449.


Beaudoin, F., Gable, K., Sayanova, O., Dunn T., and Napier, J.A. (2002) A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal b-keto-reductase. J. Biol. Chem. 277, 11481-11488.


Beaudoin, F. and Napier, J.A. (2002) Targeting and membrane insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae: The central hydrophobic domain contains more than one signal sequence and directs oleosin insertion into the endoplasmic reticulum membrane using a signal anchor sequence mechanism. Planta 215, 293-303.


Slocombe, S.P., Laurie, S., Bertini, L., Beaudoin, F., Dickinson, J.R. and Halford, N.G. (2001) Identification of SnIP1, a novel protein that interact with SNF1-related protein kinase (SnRK1). Plant Mol. Biol. 49, 31-44.


Baoxiu, Q., Beaudoin, F., Fraser, T., Stobart, A.K., Napier, J.A. and Lazarus, C.M. (2001) A cDNA from Isochrysis galbana encodes an elongase activity with substrate specificity for C18-?9 polyunsaturated fatty acids. FEBS 510, 159-165.


Napier, J.A., Beaudoin, F., Tatham, A.S., Alexander, L.G. and Shewry P.R. (2001) The seed oleosins: structure, properties and biological role. Adv. Bot. Res. 35, 111-138.


Beaudoin, F., Michaelson, L.V., Hey, S.J., Lewis, M.J., Shewry, P.R., Sayanova, O, and Napier, J.A. (2000) Production of 20 carbon polyunsaturated fatty acids in yeast. Proc. Natl. Acad. Sci. USA. 97, 6421-6426.


Beaudoin, F., Wilkinson, B.M., Stirling, C. J. and Napier, J.A. (2000) in vivo targeting of a sunflower oil body protein in yeast secretory (sec) mutants. Plant J. 23, 159-170.


Beaudoin, F. and Napier, J.A. (2000) The targeting and accumulation of ectopically expressed oleosin in non-seed tissues of Arabidopsis thaliana. Planta 210, 439-445


Sayanova, O., Beaudoin, F., Libisch, B., Castel, A., Shewry, P.R. and Napier, J.A. (2000) Functional expression and mutagenesis of a plant D6 fatty acid desaturase in yeast. J. Exp. Bot. 52, 1581-1585.


Beaudoin, F., Lacey, D.J. and Napier, J.A. (1999) The biogenesis of the plant seed oil body: oleosin protein is synthesised by ER-bound ribosomes. Plant Physiol. Biochem. 37 (6), 481-490


Lacey*, D.J., Beaudoin*, F., Dempsey, C.E., Shewry, P.R. and Napier, J.A. (1999) The accumulation of triacylglycerol within the endoplasmic reticulum of developing seeds of Helianthus annuus (* equal contribution). Plant J. 17 (4), 397-405


Lacey, D.J., Wellner, N., Beaudoin, F., Napier, J.A. and Shewry, P.R. (1998) Secondary structure of oleosins in oil bodies isolated from seeds of safflower (Carthamus tinctorius L.) and sunflower (Helianthus annuus L.). Biochem. J. 334, 469-477



PhD in Plant cell and molecular biology (University of Paris (Orsay))


MSc in Plant physiology biochemistry and molecular genetics (University of Paris (Orsay))


BSc in Plant Biology, botany and genetics (University of Paris (Orsay))