Identification and characterisation of azole sensitivity shifts in UK populations of Mycosphaerella graminicola sampled from HGCA-Fungicide Performance winter wheat trials during 2014-2018

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Identification and characterisation of azole sensitivity shifts in UK populations of Mycosphaerella graminicola sampled from HGCA-Fungicide Performance winter wheat trials during 2014-2018

Field populations of Mycosphaerella graminicola (aka Zymoseptoria tritici, the causal agent of Septoria leaf blotch) have become stepwise less sensitive to epoxiconazole and prothioconazole. During 2012 and 2013, several new CYP51 variants were found based on novel combinations of mutations and some isolates are able to express more azole target protein (CYP51). Some of these isolates are not controlled in the glasshouse using a half label rate and more monitoring is needed to see if these isolates are accumulating in field populations throughout the UK. In addition, it is also important to continue monitoring for SDHI resistance (SDHI LINK project has finished). During 2012, one strain with a slightly lower sensitivity was found in N-Germany (reported by FRAC). This strain carried mutation T79N in succinate dehydrogenase C (SdhC), one of the three Sdh subunits involved in the binding of SDHIs. An up to date knowledge on the azole and SDHI sensitivity of the UK population is needed in order to support decision making (e.g. spray frequency, dose rate and choice of mixing partners) on fungicide inputs aiming to prolong fungicide mode of action.

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